RESEARCH PROJECTS CARRIED OUT

U.G.C. sponsored research project entitled "Synthesis of Neur otensin peptide analogues on hydrophilic polymer support".

PARTICIPATION IN WORKSHOP

Attended an international Workshop on "Computer oriented Algorithms and building expert system"

Attended an eight week part time workshop on personality Development in Discover Yourself conducted by the extension wing of the institute for Yoga and Consciousness: Andhra University.

Attended National workshop on "Sophistication in Scientific instrumentation" held by R.S.I.C, I.I.T, Madras.

A BRIEF OUTLINE OF THE RESEARCH WORK DONE

The proposer has been engaged in the field of Organic Chemistry, Macro-Molecular chemistry for the last 8 years. Development of new polymer supports for solid phase synthesis, organic synthesis and solid-phase combinatorial organic synthesis for optimization of new drug lead structures. Design and synthesis of unnatural amino acids and construction of peptidomimetic compounds. Design, synthesis and structure activity correlation studies of peptide anitibiotics and other biologically active peptide.

Selective cleavage of photosensitive chormophores from biologically important macromolecules like polypeptides for conformational studies have also been research field of the investigator. The conformational studies of polymer-bound peptide and protein sequences in solution, the use of polymer bound reagents in organic synthesis, complexation of cross-linked polymer supported aminoligands, etc have also been carried out by the investigator

LIST OF PUBLICATIONS

1. Silver ion catalysed oxidation of phenosafranine by peroxdisulphate catalytic kinetic determination of micro amount of silver.
K .P. Subhashchandran and K. M. M .Krishnapresad
Andhra university, Visakhapattanam, India.
Asian journal of chemistry Vol.4, No.4 (1992) 715-725.

2. Synthesis and characterisation of Glyceroldimethacrylate cross-linked polymethyl methacrylate: a resin for solid-phase peptide synthesis
M.Roice,K.P.Subhashchandran,A.V.Gean,J.Francliin, V N.R.Pillai
Polmer 44 (2003) 911-922

3. Synthesis of Neurotensin (8-13) peptide analogues on hydrophilic Glycerol dimethacryalte cross-linked polymethyl methacrylate resin (Communicated)

4. Gel phase synthesis of model peptides on newly developed hydrophilc tetraethyleneglycol dimethacrylate cross-linked polystyrene resin (Communicated)

SYMPOSIUM/SEMINAR(paper presentation)

1 Glycerol Dimethacrylate cross-linked Polymethyl methacrylate resin an Efficient support for Polypeptide synthesis
K.P.Subhashchandran, M. Roice, A. V. Gean, J. Franklin &V.N.R.Pillai.
School of chemical sciences,M.G.University,Kottayam,Kerala-686560,
(INTERNATIONAL SYMPOSIUM ON CURRENT TRENDS IN DRUG DISCOVERY RESEARCH. CTDDR-2001)

2. Cost effect effective synthesis of neurotensin peptide analogues and its enhanced activity during diabetics.
K. P. SubhashChandran, K. S. Vijayalekshmi and N.R.R.Pillai.
(I nternational Coference on Emerging Frontiers at the Interface of Chemistry and Biology ICB-2003.)

3. Synthesis and Characterisation of Glycerol Dimethyl Acrylate Cross Linked Poly MethylMetha Acrylate Resin-a new Solid Support For Poly Peptide synthesis
K. P. Subhashchandran, M. Roice, A. V. Gean, J. Franklin & V. N. R. Pillai.
(National Conference on Materials for the new millaneium. MATCON-2001.)

SYMPOSIUM/CONFERENCE/(participation)

1. International workshop on computer oriented Algorithm and Building Expert Systems. (sponsered by ICTP( Italy), UGC,CSIR, DST, INSA and BRNS) School of Chemistry, Andhra University, Visakhapatanam-530003.INDIA.

2. Summer School on Sophistication in Scientific Instrumentation (sponsored by DST) Indian Institute of Technology,Madras-600036.

3. The First Indian Symposium of the Protein Scoiety-Proein Structure and Function. Indian Institute of Technology, Bombay, India.